Neurodegeneration

Prof. Adrian Owen (CERC) has expertise in defining the extent, causes and consequences of cognitive dysfunction in Parkinson’s disease. His 2006 landmark paper in the journal Science demonstrated for the first time that fMRI can be used to detect awareness in patients for whom no overt behavioural response is detectable. In a seminal 2010 NEJM paper, he went on to identify a patient who was believed to be vegetative, yet could answer ‘yes’ and ‘no’ questions by wilfully modulating brain activity measured by fMRI. http://web.me.com/adrian.owen

Dr. Penny MacDonald (MD, Ph.D. CRC nominee) is a movement disorder neurologist with fellowship training in fMRI. Her expertise in evaluating Parkinson’s patients, permits better characterization of the neurological features of the patients whom we will investigate with cognitive paradigms and fMRI. Uncovering predictors of cognitive decline in Parkinson’s patients will have tremendous importance as new therapies for delaying or halting dementing processes emerge. http://www.pennymacdonald.net

Dr. Elizabeth Finger is an early career clinician-scientist in the Department of Clinical Neurological Sciences. She was chief resident in neurology at Harvard/MGH/Brigham, and then completed a 3 year research fellowship at NIMH focused on structural and functional neuroimaging and pharmacologic challenge studies. Dr. Finger is an expert in the clinical assessment of frontotemporal dementia, in using novel cognitive paradigms in combination with fMRI to delineate the neural substrates of abnormal social behaviour, and has led the international community in the study of oxytocin as a potential treatment for FTD. http://www.cnsuwo.ca/faculty/neurologists/elizabeth-finger

Dr. Micahel Borrie is a Professor in the Division of Geriatric Medicine and the Medical Director of the Aging Brain and Memory Clinic and Mild Cognitive Impairment (MCI) Clinic.  He has 25 years experience in the clinical assessment, diagnosis and management of cognitive impairment syndromes and is now President of the Canadian Centres for Clinical Cognitive Research (C5R). He is part of the growing cognitive dysfunction group and works with Prof. Bartha. http://www.schulich.uwo.ca/geriatrics/michaelborrie

Prof. Stefan Köhler is an Associate Professor of Psychology. His research addresses the neural mechanisms of human memory and the interface between memory, perception, and executive control in the human brain. He employs fMRI in combination with state-of-the-art neuroimaging analyses techniques, such as the assessment of functional and effective connectivity to advance an understanding of memory impairments that are associated with various neurological conditions, including Alzheimer’s disease and epilepsy. http://www.psychology.uwo.ca/kohler

Prof. Jessica Grahn is a new Assistant Professor of Psychology. Dr. Grahn’s expertise is in the neuroscience of music, particularly using fMRI to measure how musical rhythm engages motor areas in the brain. She has begun translational work on the use of rhythm for mitigating motor symptoms of neurological disorders like Parkinson’s disease. She collaborates with Dr. MacDonald and Dr. Jog (Dir. Of the LHSC Movement Disorders group). http://www.jessicagrahn.com

Dr. Neil Duggal is a CIHR funded neurosurgeon at LHSC and Associate Professor in the Department of Clinical Neurological Sciences. He was the first surgeon in North America to perform a cervical disc replacement and has a clinical practice heavily focused on degenerative disorders of the cervical spine. http://www.cnsuwo.ca/faculty/neurosurgeons/neil-duggal

Dr. Jorge Burneo is Co-Director of the Western University Epilepsy Program, the largest in Canada with 8 adult beds, 1 pediatric bed and 4 neurosurgeons (2 adult, 1 pediatric and 1 doing both). All beds are monitored 24/7. He is Co-PI of the “Epilepsy Discovery” project recently funded by the Ontario Brain Institute. http://www.cnsuwo.ca/faculty/neurologists/jorge-burneo. He and his colleague

Dr. Seyed Misrsattari (an MD/Ph.D.), use neuroimaging techniques to assess plasticity of brain function and metabolic impairments in patients with intractable epilepsy, as well as mapping brain function using fMRI in candidates for epilepsy surgery. Dr. Mirsattari was a pioneer in the novel design and implementation of MRI compatible scalp and implanted electrodes for real time readout in the MRI scanner. http://www.cnsuwo.ca/faculty/neurologists/seyed-mirsattari

Dr. Marcelo Kremenchutzky is the Director of the Multiple Sclerosis Clinic in London, one of the larges MS clinics in the world with over 8000 patients. He is a Consultant Neurologist at the London Health Sciences Centre – University Hospital. main interest is the study of MS and other demyelinating disorders, focusing on the epidemiology, natural history and treatment of this still mysterious disease. His most recent research has focused on the much under investigated nature of progressive MS and he has teamed up with Menon to exploit the novel MS imaging capabilities of the 3T and 7T scanners. http://www.cnsuwo.ca/faculty/neurologists/marcelo-kremenchutzky