Graduate Student, Western University
Profile & Research Interests
Alzheimer’s disease is characterized by specific cellular, metabolic, and anatomical changes in the brain, often present years before changes in memory and cognition are apparent. Detecting such changes is challenging, but offers the possibility to predict which people may suffer from dementia and who could benefit from early treatment. An important feature of Alzheimer’s disease – the increased concentration of a special enzyme called Cathepsin-D may allow early differentiation of normal subjects from subjects with the disease. Mouse models are needed for the initial development of a compound that could be used to detect Cathepsin-D using MRI. This project will Identify an appropriate mouse model of Familial Alzheimer Disease that has increased Cathepsin-D similar to that observed in humans, and optimize an optical imaging procedure in the mouse brain to visualize the compound designed to detect Cathepsin-D.
- Panels A-D illustrate SN56 neuronal cells transfected with human cathepsin-
D. The first set of panels (a and e) is the DIC image of SN56 cells. The second column
of images (c and f) displays the fluorescence coming from the red channel. The third set
of panels (c and g) show fluorescence obtained from the green channel. Lastly, the fourth
panel (d and h) demonstrates the overlay of both red and green channels. The bottom row
of images (e-h) are control SN56 cells. (Courtesy of Rob Ta 2012).
- Coming Soon!
- Labelling dendritic cells with SPIO has implications for their subsequent in vivo migration as assessed with cellular MRI. de Chickera SN, Snir J, Willert C, Rohani R, Foley R, Foster PJ, Dekaban GA. Contrast Media Mol Imaging. 2011 Jul-Aug;6(4):314-27.
- Semiquantitation of mouse dendritic cell migration in vivo using cellular MRI. Dekaban GA, Snir J, Shrum B, de Chickera S, Willert C, Merrill M, Said EA, Sekaly RP, Foster PJ, O’Connell PJ. J Immunother. 2009 Apr;32(3):240-51.
- Imaging islets labeled with magnetic nanoparticles at 1.5 Tesla. Tai JH, Foster P, Rosales A, Feng B, Hasilo C, Martinez V, Ramadan S, Snir J, Melling CW, Dhanvantari S, Rutt B, White DJ. Diabetes. 2006 Nov;55(11):2931-8.
Recent Publications on Pubmed: J Snir
Awards & Scholarships
- Coming Soon!